| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7630608 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 7 Pages |
Abstract
- A simple, selective and sensitive UPLC-MS/MS method was developed and validated.
- The method provides a LOQ of 10 ng mLâ1 allowing the quantification of clindamycin in the vitreous humor.
- The drug administrated by intravitreal injections remained in the vitreous cavity for 2 weeks.
- The clindamycin-loaded PLGA implant released the drug up to 6 weeks.
- The implant showed to be biocompatible.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Gabriella M. Fernandes-Cunha, Dayana Rubio Gouvea, Gustavo de Oliveira Fulgêncio, CÃntia M.F. Rezende, Gisele Rodrigues da Silva, Juliana M. Bretas, SÃlvia Ligório Fialho, Norberto Peporine Lopes, Armando Silva-Cunha,