| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7630620 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 8 Pages |
Abstract
- MH84 was identified as γ-secretase modulator and PPARγ agonist (Alzheimer's disease).
- We developed and validated a sensitive LC-MS method for MH84.
- A pharmacokinetic animal study (mice) was performed.
- Unmetabolized MH84 was found in plasma and brain tissue.
- MH84 penetrates the blood-brain-barrier without long-term accumulation in CNS.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
M. Pellowska, C. Stein, M. Pohland, D. Merk, J. Klein, G.P. Eckert, M. Schubert-Zsilavecz, M. Wurglics,