| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7630637 | Journal of Pharmaceutical and Biomedical Analysis | 2015 | 23 Pages |
Abstract
- An HPLC method was developed for 3,4,3-LI(1,2-HOPO), a radionuclide decorporating agent.
- 3,4,3-LI(1,2-HOPO) was derivatized to its iron complex to be analyzed as one single peak.
- Reagent ratio, pH and derivatization conditions were optimized.
- The HPLC method was validated per ICH guidelines and used in stability studies.
- Total of 11 impurities were identified by HRMS and MS/MS fragments.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Mingtao Liu, Jennie Wang, Xiaogang Wu, Euphemia Wang, Rebecca J. Abergel, David K. Shuh, Kenneth N. Raymond, Paul Liu,