Investigation of antibody disulfide reduction and re-oxidation and impact to biological activities

- Whether partial reduction a concern for safety or efficacy was addressed.
- Partially reduced mAb subclasses were re-oxidized quickly in vitro.
- The re-oxidized mAbs are fully assembled/indistinguishable from drug products.
- Partially reduced mAbs are fully potent in cell-based bioassay.
- These results will be very helpful to address concerns from regulatory agencies.