| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7630741 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 6 Pages |
Abstract
- Ascorbic acid on dissolution stability and bioavailability of rifampicin in the presence of isoniazid was studied.
- Rifampicin and its metabolite 3-FRSV were analyzed by dual wavelength spectroscopy.
- Ascorbic acid significantly reduced rifampicin degradation and formation of 3-FRSV in acid medium.
- In vitro dissolution stability correlated with in vivo bioavailability of rifampicin.
Related Topics
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Authors
Subashini Rajaram, Venkata Deepthi Vemuri, Rajendran Natham,