| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7630743 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 7 Pages |
Abstract
- Hydroxychloroquine and its metabolites were quantified in whole blood by LC-MS/MS.
- The method was fully validated for all compounds according to EMA guidelines.
- The assay was suitable for concentrations.
- 20,000Â ng/mL after sample dilution.
- The method was successfully applied to a blood sample after massive poisoning.
- Monitoring metabolites in treatment or overdose needs to be assessed.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Marion Soichot, Bruno Mégarbane, Pascal Houzé, Lucie Chevillard, Julien Fonsart, Frédéric J. Baud, Olivier Laprévote, Emmanuel Bourgogne,