| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631179 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 8 Pages |
Abstract
- Measurement of TFV and FTC in dried blood spot to 2.5Â ng/mL.
- DBS storage requires â20 °C or below because phosphate anabolites degrade to TFV.
- Measurement was accurate and precise for hematocrit spanning the normal range.
- Measurement was not impacted by punch location and spot volumes (10-50 μL).
- DBS can be used as a plasma alternative for pharmacokinetic analyses in vivo.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jia-Hua Zheng, Louis A. Guida, Caitlin Rower, Jose Castillo-Mancilla, Amie Meditz, Brandon Klein, Becky Jo Kerr, Jacob Langness, Lane Bushman, Jennifer Kiser, Peter L. Anderson,