| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631191 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 8 Pages |
Abstract
- 2-PMPA is a potent and selective glutamate carboxypeptidase II inhibitor.
- 2-PMPA has shown efficacy in >20 animal models of neurological/psychiatric diseases.
- Bioanalysis of 2-PMPA has been challenging due to its multiple negative charges.
- We report derivatization method enabling 2-PMPA detection by LC/MS/MS.
- We report, for first time, 2-PMPA plasma pharmacokinetics and tissue distribution.
Keywords
time to CmaxCXPPSMANAALADaseHQCNAAG2-PMPAtmaxMtBSTFALLOQDRGMQCCmaxLQCdorsal root ganglionAUCProstate specific membrane antigencollision energyANOVAone-way analysis of variancemaximum plasma concentrationPharmacokineticslower limit of quantitationDerivatizationarea under the concentration–time curvedeclustering potentialcollision cell exit potentialentrance potentialhigh quality controllow quality control
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Rana Rais, Camilo Rojas, Krystyna Wozniak, Ying Wu, Ming Zhao, Takashi Tsukamoto, Michelle A. Rudek, Barbara S. Slusher,