| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631270 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 6 Pages |
Abstract
- A LC-MS/MS method was first developed and validated for the determination of deoxypodophyllotoxin in rat plasma.
- Good peak shape and sensitivity with acceptable matrix effect could be obtained.
- It is the first pharmacokinetic study of the intravenous administration of DPT in rats.
- The pharmacokinetic parameters were obtained through two-compartment intravenous models analysis.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Yang Yang, Yang Chen, Ze-Yu Zhong, Ji Zhang, Feng Li, Ling-Ling Jia, Li Liu, Xiong Zhu, Xiao-Dong Liu,