| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631280 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 12 Pages |
Abstract
- EAPB0503 was a promising novel anti-cancer drug.
- Phase I and phase II metabolites of EAPB0503 were characterized using LC-ESI-MS/MS.
- On-line H/D exchange experiments were also employed in metabolite identification.
- In vitro metabolism studies with liver microsomes and hepatocytes were performed.
- Four phase I and 3 phase II metabolites were characterized.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Florian Lafaille, Isabelle Solassol, Christine Enjalbal, Benjamin Bertrand, Pierre-Emmanuel Doulain, Johanna Vappiani, Pierre-Antoine Bonnet, Carine Deleuze-Masquéfa, Françoise M.M. Bressolle,