| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631303 | Journal of Pharmaceutical and Biomedical Analysis | 2014 | 10 Pages |
Abstract
- Quantified an epothilone-folate conjugate and its epothilone moiety in plasma.
- Evaluated the stability of the disulfide and ester containing compounds in plasma.
- A cocktail of NEM and PMSF effectively stabilized both analytes in plasma.
- ISR helps identifying the minor conversion from BMS-753493 to BMS-748285.
- The validated method was successfully applied to support clinical studies.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Long Yuan, Wenying Jian, Duxi Zhang, Anne-Françoise Aubry, Mark E. Arnold,