Application of an innovative design space optimization strategy to the development of LC methods for the simultaneous screening of antibiotics to combat poor quality medicines

- Innovative design space methodology to develop generic and specific HPLC methods.
- Involvement of 19 molecules of pharmaceutical interest mainly targeted by counterfeit.
- Evaluation of the robustness of the predicted DS through geometric transfer while providing fast methods of analysis.
- Validation of the UHPLC method using the accuracy profile as decision tool.
- Confirmation of the poor quality of medicines phenomenon through quantification of real samples.