| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631508 | Journal of Pharmaceutical and Biomedical Analysis | 2013 | 9 Pages |
Abstract
- Forced degradation on idarubicin under ICH Q1A(R2) prescribed conditions conducted.
- Three new degradation products of idarubicin characterized through LC-MS-TOF studies.
- Acid hydrolyzed product characterized as deglucosaminyl idarubicin.
- Two oxidative products characterized as desacetyl idarubicin and desacetyl idarubicin hydroperoxide.
- Mechanistic explanation of idarubicin degradation discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Dheeraj Kaushik, Gulshan Bansal,