| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631640 | Journal of Pharmaceutical and Biomedical Analysis | 2013 | 9 Pages |
Abstract
- A memantine LC-MS method was developed in perfusate and mouse brain homogenate.
- An in situ transcardiac perfusion mouse model was validated in our laboratory.
- Application of the methods demonstrated reduced brain uptake of memantine in a mouse model of Alzheimer's disease.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Dharmini C. Mehta, Jennifer L. Short, Joseph A. Nicolazzo,