| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631719 | Journal of Pharmaceutical and Biomedical Analysis | 2013 | 4 Pages |
Abstract
- We employed hydrogel nanoparticles to concentrate urinary hGH into the linear range of isoform differential immunoassays.
- The pre-processing step allowed measurement of urine spiked with recombinant and pituitary hGH.
- Nanoparticles pre-treatment was applied to urine from healthy volunteers administered with recombinant hGH.
- The recombinant/pituitary hGH concentration ratios remained above the established WADA criterion for hGH misuse up to 24Â h after the last administration dose.
- The use of nanoparticles appears to open the possibility of assessing rhGH misuse in urine.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jaume Bosch, Alessandra Luchini, Simona Pichini, Davide Tamburro, Claudia Fredolini, Lance Liotta, Emanuel Petricoin, Roberta Pacifici, Francesco Facchiano, Jordi Segura, Enrico Garaci, Ricardo Gutiérrez-Gallego,