The profiling and identification of the absorbed constituents and metabolites of Paeoniae Radix Rubra decoction in rat plasma and urine by the HPLC-DAD-ESI-IT-TOF-MSn technique: A novel strategy for the systematic screening and identification of absorbed

- A novel strategy to find absorbed constituents and metabolites of TCMs was proposed.
- Absorption and metabolism of Paeoniae Radix Rubra were studied for the first time.
- 13 new absorbed constituents of Paeoniae Radix Rubra were reported for the first time.
- 90 new metabolites of PRR decoction were tentatively identified by LC-MS technique.
- 22 new metabolites of paeoniflorin were reported for the first time.