| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7631856 | Journal of Pharmaceutical and Biomedical Analysis | 2013 | 12 Pages |
Abstract
- A robust assay was validated to quantify BMS-927711, a drug candidate, in plasma.
- A simplified method optimization strategy was used to develop this robust assay.
- An N-carbamoyl glucuronide metabolite was evaluated to minimize its conversion risk.
- Excellent assay robustness, precision and accuracy were achieved.
- It has been applied to non-clinical toxicokinetic studies in different species.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Naiyu Zheng, Jianing Zeng, Billy Akinsanya, Adela Buzescu, Yuan-Qing Xia, Van Ly, Kevin Trouba, Qianping Peng, Anne-Françoise Aubry, Mark E. Arnold,