| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7632088 | Journal of Pharmaceutical and Biomedical Analysis | 2013 | 6 Pages |
Abstract
⺠The authors describe the use of the homogeneous mobility shift assay (HMSA). ⺠HMSA was used to measure adalimumab and antibodies-to-adalimumab (ATA). ⺠The HMSAs for adalimumab and ATA have high sensitivity, precision and accuracy. ⺠Non-responding patients showed high incidence of ATA generation (44%) using HMSA. ⺠In non-responding patients, levels of adalimumab and ATA were inversely associated.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Shui-Long Wang, Scott Hauenstein, Linda Ohrmund, Reshma Shringarpure, Jared Salbato, Rukmini Reddy, Kevin McCowen, Shawn Shah, Steven Lockton, Emil Chuang, Sharat Singh,