A UPLC-MS/MS method for the simultaneous plasma quantification of all isomeric forms of the new anti-HCV protease inhibitors boceprevir and telaprevir

Article ID	Journal	Published Year	Pages	File Type
7632136	Journal of Pharmaceutical and Biomedical Analysis	2013	34 Pages	PDF

Abstract

âº First method to simultaneously quantify telaprevir and boceprevir isomers. âº We use human acidified plasma, avoiding the transition from one isomer to another. âº The first time use of UPLC-MS/MS, allowing a short and high selective run. âº We use a easy to buy and cheap IS (quinoxaline). âº The extraction procedure is very fast and cheap (No SPE cartridges).

Keywords

Telaprevir UPLC–MS/MS Boceprevir HCV Plasma

Related Topics

Physical Sciences and Engineering Chemistry Analytical Chemistry

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A UPLC-MS/MS method for the simultaneous plasma quantification of all isomeric forms of the new anti-HCV protease inhibitors boceprevir and telaprevir

Authors

Antonio D'Avolio, Amedeo De NicolÃ², Danilo Agnesod, Marco Simiele, Adnan Mohamed Abdi, Sujan Dilly Penchala, Lucio Boglione, Giuseppe Cariti, Giovanni Di Perri,