| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7632349 | Journal of Pharmaceutical and Biomedical Analysis | 2013 | 8 Pages |
Abstract
⺠Tamoxifen is the most widely used drug in breast cancer treatment. ⺠Most of the biological activity of tamoxifen is due to the metabolite endoxifen, formed mainly by CYP2D6 hydroxilation of N-demethyltamoxifen. ⺠We developed the most sensitive HPLC-UV method for the determination of plasma concentrations of tamoxifen, endoxifen and other revelevant metabolites. ⺠The method was tested in 110 plasma samples from breast cancer patients under tamoxifen therapy and endoxifen was always above the limit of detection. ⺠Endoxifen can be measured with adequate accuracy and precision in clinical samples by the developed method.
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Authors
Marina Venzon Antunes, Daniela Dornelles Rosa, Tamyris dos Santos Viana, Huander Andreolla, Tiago Ozelame Fontanive, Rafael Linden,