| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7632350 | Journal of Pharmaceutical and Biomedical Analysis | 2013 | 10 Pages |
Abstract
⺠We established two LRRK2 ELISA's. ⺠Serine 935 phosphorylation is used as readout for LRRK2 activity. ⺠One assay can be used to screen for cellular active LRRK2 inhibitors. ⺠We present an ELISA to measure in vivo pS935 LRRK2 levels. ⺠With this assay we demonstrate in vivo efficacy of a LRRK2 inhibitor.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Lore Delbroek, Kristof Van Kolen, Liesbeth Steegmans, Raquel da Cunha, Wim Mandemakers, Guy Daneels, Pieter-Jan De Bock, Jinwei Zhang, Kris Gevaert, Bart De Strooper, Dario R. Alessi, Patrik Verstreken, Diederik W. Moechars,