| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7633162 | Journal of Pharmaceutical and Biomedical Analysis | 2012 | 6 Pages |
Abstract
⺠Unidentified NMR signal in the 2.10-3.20 ppm range is non compliant to the heparin US monograph. ⺠Some heparin sources containing an extra signal at 2.18 ppm were depolymerized by heparinase I. ⺠Heparin fractions were purified by LC to enrich moiety responsible of the NMR extra signal. ⺠From our investigation, a specific tetrasaccharide bearing an extra acetyl group was isolated. ⺠This chemical modification is characteristic of the heparin manufacturing process.
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Physical Sciences and Engineering
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Analytical Chemistry
Authors
Pierre A.J. Mourier, Olivier Y. Guichard, Fréderic Herman, Christian Viskov,