Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7635154 | Journal of Proteomics | 2016 | 45 Pages |
Abstract
Understanding the mechanism of extracellular vesicles such as exosomes in breast cancer progression and identification of molecular biomarker candidates for breast cancer are of great significance. Exosomes, which function as informative vesicles, can help to understand disease mechanisms and are ideal candidates for identification of diagnostic biomarker for various diseases. Here, we identified the molecular mechanism of action of EDIL3 on extracellular vesicles in breast cancer and its role in vivo, and a biomarker candidate for metastatic breast cancer. Furthermore, it is suggested that EDIL3 might be employed as a therapeutic target that limits disease progression.
Keywords
UPLCXICEVStetramethylethylenediamineTEMEDMVBGBMFAKNTADLSEGFFDRTemmultivesicular bodiestriethylammonium bicarbonateCancer biomarkerNanoparticle tracking analysisEMTExtracellular vesiclesCancer invasionconditioned mediaBreast cancerepidermal growth factorfalse discovery rateTransmission electron microscopeDynamic Light Scatteringultra performance liquid chromatographyextracted ion chromatogramfocal adhesion kinaseGlioblastoma multiforme
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jeong-Eun Lee, Pyong-Gon Moon, Young-Eun Cho, Young-Bum Kim, In-San Kim, Hoyong Park, Moon-Chang Baek,