Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7638196 | Journal of Proteomics | 2013 | 12 Pages |
Abstract
⺠Prion protein conversion was characterized by structural proteomics methods. ⺠Limited proteolysis, surface modification, HDX, and crosslinking were used. ⺠Data from multiple approaches indicate rearrangement of the H1-β2/H2-H3 interface. ⺠The H1-β2-rigid loop is the region of conformational change during prion conversion.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jason J. Serpa, Aileen P. Patterson, Jingxi Pan, Jun Han, David S. Wishart, Evgeniy V. Petrotchenko, Christoph H. Borchers,