Article ID Journal Published Year Pages File Type
7638201 Journal of Proteomics 2013 10 Pages PDF
Abstract
► Unbiased evaluation of CK2 inhibitors using inhibitor affinity Sepharose ► Binding of CK2 to a TBB-related inhibitor is validated in complex mixtures. ► Nucleotide-binding proteins identified as targets for TBB-related CK2 inhibitors. ► Binding to abundant cellular proteins may limit inhibitor bioavailability.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Preview
Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2
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