| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7638503 | Journal of Proteomics | 2012 | 11 Pages |
Abstract
⺠Erythrocytes were used to assess its role in the pathophysiology of COPD. ⺠Differential 16O/18O stable isotope labeling was employed for relative quantitation. ⺠A total 219 proteins were quantified as differentially expressed in COPD patients. ⺠VPS13A was found down-regulated in COPD patients which may be related to erythrocyte deformation in COPD. ⺠CYB5R3 was found down-regulated in COPD suggesting higher risk of methemoglobinemia among COPD patients.
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Authors
Bruno M. Alexandre, Nuno Charro, Josip Blonder, Carlos Lopes, Pilar Azevedo, António Bugalho de Almeida, King C. Chan, DaRue A. Prieto, Haleem Issaq, Timothy D. Veenstra, Deborah Penque,