Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7638939 | Journal of Trace Elements in Medicine and Biology | 2018 | 72 Pages |
Abstract
Iron plays a key role in infectious diseases both as modulator of the innate immune response and as nutrient for microbes. We need to gain a more comprehensive understanding of how the body can differentially respond to infection by extra- or intracellular pathogens. This knowledge may allow us to modulate mammalian iron homeostasis pharmaceutically and to target iron-acquisition systems of pathogens, thus enabling us to treat infections with novel strategies that act independent of established antimicrobials.
Keywords
CREBNF-κBLPSJnkTransferrinRPMmRNAROIHFENrf2NADPHDAMPEPOMDSRBCSLCIFN-γHIF-1αPAMPTLRMFSPRRDMT1ZIPNOS2RCTSOCSIRPNGALHMOX1HJVM-CSFPCBP2IRETfR1NRAMP1ferroportinNTBISMADLCN2T helperDcytBduodenal cytochrome BFpn1TIMnuclear factor erythroid 2-related factor-2MRP1FTHERRγHpxFTLNF-IL6STEAPNCOA4TBIHcp1Haeme oxygenase-1TNFSCARA5hepcidin antimicrobial peptideCCAAT enhancer-binding proteinJanus kinaseC/EBPc-Jun N-terminal kinaseDNAScTAdenosine TriphosphateATPRandomized controlled trialSTATIroniron-regulatory proteinErythroferroneerythropoietindeoxyribonucleic acidDanger-associated molecular patternpathogen-associated molecular patterninterferon-γinterleukinMajor facilitator superfamilyToll-like receptorsolute carriercluster of differentiationmessenger ribonucleic acidFerritin Heavy ChainFerritin Light Chainsuppressor of cytokine signalingNK cellDendritic cellNatural killer cellKupffer cellmyelodysplastic syndromemononuclear phagocyte systemhypoxia-inducible factor-1αtumour necrosis factorInfectioniron-responsive elementNon-transferrin bound ironnuclear factor-κBFerritinneutrophil gelatinase-associated lipocalinlipopolysaccharideMacrophageMHCmajor histocompatibility complexBMPUTR یا untranslated regions untranslated regioncarbon monoxideMPsNitric oxidenicotinamide adenine dinucleotide phosphateHAMPAREhereditary haemochromatosisHaemopexinhaemoglobinHepcidinReactive oxygen intermediatescyclic adenosine monophosphate response element-binding proteinMultidrug resistance protein-1Bone morphogenetic proteinStem cell transplantationJAKred blood cellpattern recognition receptorScavenger receptor
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Manfred Nairz, Stefanie Dichtl, Andrea Schroll, David Haschka, Piotr Tymoszuk, Igor Theurl, Günter Weiss,