Iron and innate antimicrobial immunity-Depriving the pathogen, defending the host

Article ID	Journal	Published Year	Pages	File Type
7638939	Journal of Trace Elements in Medicine and Biology	2018	72 Pages	PDF

Abstract

Iron plays a key role in infectious diseases both as modulator of the innate immune response and as nutrient for microbes. We need to gain a more comprehensive understanding of how the body can differentially respond to infection by extra- or intracellular pathogens. This knowledge may allow us to modulate mammalian iron homeostasis pharmaceutically and to target iron-acquisition systems of pathogens, thus enabling us to treat infections with novel strategies that act independent of established antimicrobials.

Keywords

CREB NF-κB LPS Jnk Transferrin RPM mRNA ROI HFE Nrf2 NADPH DAMP EPO MDS RBC SLC IFN-γ HIF-1α PAMP TLR MFS PRR DMT1 ZIP NOS2 RCT SOCS IRP NGAL HMOX1 HJV M-CSF PCBP2 IRE TfR1 NRAMP1 ferroportin NTBI SMAD LCN2 T helper DcytB duodenal cytochrome B Fpn1 TIM nuclear factor erythroid 2-related factor-2 MRP1 FTH ERRγ Hpx FTL NF-IL6 STEAP NCOA4 TBI Hcp1 Haeme oxygenase-1 TNF SCARA5 hepcidin antimicrobial peptide CCAAT enhancer-binding protein Janus kinase C/EBP c-Jun N-terminal kinase DNA ScT Adenosine Triphosphate ATP Randomized controlled trial STAT Iron iron-regulatory protein Erythroferrone erythropoietin deoxyribonucleic acid Danger-associated molecular pattern pathogen-associated molecular pattern interferon-γ interleukin Major facilitator superfamily Toll-like receptor solute carrier cluster of differentiation messenger ribonucleic acid Ferritin Heavy Chain Ferritin Light Chain suppressor of cytokine signaling NK cell Dendritic cell Natural killer cell Kupffer cell myelodysplastic syndrome mononuclear phagocyte system hypoxia-inducible factor-1α tumour necrosis factor Infection iron-responsive element Non-transferrin bound iron nuclear factor-κB Ferritin neutrophil gelatinase-associated lipocalin lipopolysaccharide Macrophage MHC major histocompatibility complex BMP UTR یا untranslated regions untranslated region carbon monoxide MPs Nitric oxide nicotinamide adenine dinucleotide phosphate HAMP ARE hereditary haemochromatosis Haemopexin haemoglobin Hepcidin Reactive oxygen intermediates cyclic adenosine monophosphate response element-binding protein Multidrug resistance protein-1 Bone morphogenetic protein Stem cell transplantation JAK red blood cell pattern recognition receptor Scavenger receptor