Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7639096 | Journal of Trace Elements in Medicine and Biology | 2017 | 10 Pages |
Abstract
In this study, we developed, characterized and evaluated the antioxidant activity of poly (lactic acid) nanoparticles containing diphenyl diselenide (PhSe)2. Nanoparticles were characterized in terms of mean particle size, polydispersity index, zeta potential, encapsulation efficiency, in vitro release profile, physical stability, polymer-drug interactions and thermal properties. Also, the antioxidant activity of nanoparticles on hypochlorous acid (HOCl) was assessed. Nanoparticles presented a mean size of 210Â nm, had low polydispersity, zeta potential of â24Â mV, and an encapsulation efficiency over 90%. Differential scanning calorimetry and X-ray diffraction results showed (PhSe)2 is dispersed in PLA matrix in an amorphous state. Lyophilized nanoparticles maintained physical stability over three months, while nanoparticles dispersed in water did not present stability over 7Â days. In vitro release assay was characterized by a biphasic release pattern with burst effect in 8Â h followed by a sustained release diffusion governed over 192Â h. Nanoencapsulation did not alter the antioxidant activity of (PhSe)2 on HOCl. The study concludes these properties of (PhSe)2-loaded nanoparticles can be useful to extend the biological effects of (PhSe)2.
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Authors
Osmar dos Reis Antunes Junior, Emilli Antônio, Rubiana Mara Mainardes, Najeh Maissar Khalil,