Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7639343 | Journal of Trace Elements in Medicine and Biology | 2016 | 24 Pages |
Abstract
Manganese (Mn) overexposure induced neurological damages, which could be potentially protected by sodium para-aminosalicylic acid (PAS-Na). In this study, we systematically detected the changes of divalent metal elements in most of the organs and analyzed the distribution of the metals in Mn-exposed rats and the protection by PAS-Na. Sprague Dawley (SD) rats received intraperitoneal injections of 15 mg/kg MnCl2·4H2O (5 d/week for 3 weeks), followed by subcutaneous (back) injections of PAS-Na (100 and 200 mg/kg, everyday for 5 weeks). The concentrations of Mn and other metal elements [Iron (Fe), Copper (Cu), Zinc (Zn), Magnesium (Mg), Calcium (Ca)] in major organs (liver, spleen, kidney, thighbone and iliac bone, cerebral cortex, hippocampus and testes) and blood by Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES). The results showed that Mn overexposure significantly increased Mn in most organs, Fe and Zn in liver, Fe and Mg in blood; however decreased Fe, Cu, Zn, Mg and Ca in cortex, Cu and Zn in kidney, Cu and Mg in iliac bone, and Zn in blood. In contrast, PAS-Na treatment restored most changes particularly in cortex. In conclusion, excessive Mn exposure disturbed the balance of other metal elements but PAS-Na post-treatments could restore these alterations.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Zong-Xiang Yuan, Hai-Bin Chen, Shao-Jun Li, Xiao-Wei Huang, Yu-Huan Mo, Yi-Ni Luo, Sheng-Nan He, Xiang-Fa Deng, Guo-Dong Lu, Yue-Ming Jiang,