Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7639379 | Journal of Trace Elements in Medicine and Biology | 2015 | 17 Pages |
Abstract
Potassium iodate (KIO3) and potassium iodide (KI) are the major salt iodization agents used worldwide. Unlike iodide (Iâ), iodate (IO3â) should be reduced to Iâ before it can be effectively used by the thyroid. In this study, we developed a new method for analyzing IO3â and Iâ in tissue homogenates using high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS). We further applied the method to demonstrate the KIO3 reduction process by tissues in vitro. The effects of KIO3 on the total antioxidative activity (TAA) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) were also investigated here. Finally, we found that IO3â can be reduced to Iâ by tissue homogenates and IO3â irreversibly decreases the antioxidant capability of tissues. Our studies suggest that KIO3 might have a big effect on the redox balance of tissue and would further result in oxidative stress of organisms.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Xiaoxiao Cao, Wei Ma, Liejun Liu, Jing Xu, Haiyan Wang, Xiuwei Li, Jiangqing Wang, Jianhua Zhang, Zexi Wang, Yunyou Gu,