Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7640579 | Microchemical Journal | 2018 | 30 Pages |
Abstract
In this work, a graphene modified by Fe3O4 nanoparticles (G-Fe3O4) was prepared and characterized. Seven chiral imidazole antifungals, including ketoconazole, econazole, miconazole, butoconazole, sertaconazole, fenticonazole and isoconazole were extracted from three environmental water samples by magnetic solid-phase extraction based on the G-Fe3O4, followed by enantiomeric analysis on a Chiralcel OJ-RH column coupled with a triple quadrupole mass spectrometry to evaluate their possible stereoselectivity during the degradation process occurring in the environment. Method detection and quantification limits for all the enantiomers were 0.11-0.32â¯ng/L and 0.28-0.67â¯ng/L, respectively. Satisfactory recovery (70-92%), good intra-day precision (RSD 3.1-12.0%) and inter-day precision (RSD 3.0-10.1%) were also obtained. Furthermore, the possible interactions between the analyte and graphene, such as electrostatic attraction, cation-Ï interaction, hydrophobic interaction and Ï-Ï stacking were discussed by combining the experiment results and molecular docking study, which provided a new insight into the adsorption mechanism of analytes on graphene.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Zhaokun Wang, Pengfei Zhao, Jia Yu, Zhen Jiang, Xingjie Guo,