| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7640786 | Microchemical Journal | 2018 | 22 Pages |
Abstract
Although DNA assembly-based nanomachines or nanodevice have been intensively studied, the application of DNA nanomachines can be suffered from the slow kinetic of DNA assembly. Herein, we integrated a branched DNAzyme into synthetic DNA motors, thus significantly accelerating the operation of DNA motors. Compared with DNA motors built by a single DNAzyme, the branched DNAzyme DNA nanomotor has much faster operation features. For the application, it could detect as low as 100Â fM thrombin within 45Â min. The strategy endowed the DNA nanomotor a great potentiality to the analytical application in clinical diagnosis.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Huan Du, Peng Yang, Xin Hou, Xiandeng Hou, Junbo Chen,