A green cyclodextrin metal-organic framework as solid-phase extraction medium for enrichment of sulfonamides before their HPLC determination

A facile approach was used to prepare a cyclodextrin metal-organic framework(CD-MOF) based on γ-cyclodextrins (γ-CDs) and alkali metal cations. As a green, renewable framework material, the CD-MOF exhibits high selectivity and sorptive capacity toward sulfonamides (SAs). Therefore, five SAs including sulfathiazloe(STZ), sulfamethoxymidine(SMD), sulfamerazine(SMR), sulfadimethoxine (SDM)and sulfaquinoxaline (SQX) were selected as target analytes to validate the extraction performance of CD-MOF as a solid-phase extraction (SPE) adsorbent, coupled with high-performance liquid chromatography (HPLC) and the adsorption mechanism was investigated. The results showed that the CD-MOF as adsorbent exhibited good enrichment capability for five SAs and obtained short adsorption equilibrium time(30 min). Under optimized conditions, the spiked recoveries into meat samples were satisfied (76%-102%) with relative standard deviation below 2.4%-6.5% (n = 3) which indicated that the method was suitable for the effective extraction of SAs from complicated matrices.