Mécanismes physiopathologiques du rétrécissement aortique calcifié

Calcified Aortic Valve Disease (CAVD) is a common cardiovascular disease. It consists in a fibrotic and calcified rearrangement of the aortic valve, which leads to major valvular insufficiency. From the onset of symptoms (as dyspnea or angina), and without prompt management, patient survival is dramatically diminished. Pathophysiological mechanisms of aortic stenosis are little known, although many advances in this area have been done. Our review aims to explore the histology and physiology of the valves, and then, focuses on molecular and cellular mechanisms involved in the origin of the disease.