| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7645984 | Revue Francophone des Laboratoires | 2016 | 8 Pages |
Abstract
Intestinal inflammatory diseases are relatively frequent autoimmune diseases among the population. Clinical examination, radiology, endoscopy and biology shall be combined in order to diagnose these pathologies and allow their monitoring. Biology is not only a help in the diagnosis of intestinal inflammatory diseases but also a help to distinguish Crohn's disease from ulcerative colitis. These markers are also interesting in preventing relapses, complications, monitoring of remission and are involved in decision algorithms for therapeutic care. Various types of markers will be described and developed in this review such as, serum antibodies, fecal proteins and pharmacological monitoring of biotherapies. The therapeutic adaptation (dose optimization, treatment cessation) and the time spacing of invasive procedures such as endoscopy correspond to major advances allowed by these biomarkers.
Keywords
ANCARCHACCAASCAGP2AdalimumabIFXAMCAPAPTNFGM-CSFTLRALCAantibodiesImmunoglobulineInfliximabmaladies inflammatoires chroniques de l’intestinMaladies inflammatoiresCrohn's diseaseBiotherapyBiotherapiestumor necrosis factorMaladie de CrohnToll like receptorsgranulocyte macrophage colony-stimulating factorADAAnticorpsprotéine C réactiveCRPFecal calprotectinrectocolite hémorragiqueUlcerative colitisMICI
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Alexandre Jentzer, Anne-Emmanuelle Depincé-Berger, Christian Genin, Xavier Roblin, Stéphane Paul,