Apport des méthodes d'isolement immunomagnétique de lymphocytes T cytotoxiques dans la restauration rapide d'une immunité antivirale après allogreffe de cellules souches hématopoïétiques

Viral infections represent one of the main causes of morbidity and mortality following Hematopoietic Stem Cell Transplantation. Anti-viral treatment failure may be explained by absence of specific immune reconstitution. Anti-viral immunotherapy relies on isolation of mono or multi-virus donor-derived-specific T cells with or without in vitro expansion. During the last ten years, such an adoptive transfer has been proved feasible, safe and helpful in specific anti-viral immune reconstitution. Today, immunomagnetic isolation methods present the advantages to be fast, and to allow a good reactivity to propose immunotherapy in case of anti-viral treatment failure.