| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7662277 | Revue Francophone des Laboratoires | 2008 | 8 Pages |
Abstract
Specific genotypes of high risk human papillomaviruses are responsible of cervical cancer, the second tumor in women worldwide. Cellular transformation and maintenance of the malignant phenotype are mainly linked to the expression of the viral E6 and E7 proteins. These oncoproteins target many cellular proteins involved in cell cycle regulation, apoptosis control, DNA repair, spindle formation, intercellular and cell-extracellular matrix adhesion, cell motility and mitogenic signal transduction pathways.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Christiane Mougin, Magali Nicolier, Anne-Zélie Decrion-Barthod,