Suivi des profils de stéroïdes urinaires dans le contrôle du dopage des sportifs

Detecting and confirming the administration of an anabolic androgenic steroid that could be present normally in the human body is a complex task. Markers of utilisation, parameters of the urinary steroid profile were identified. Their precise measurement by GC/MS in routine operations is essential to establish reference ranges in the athletic population, to determine their individual stability, and to detect anomalies in an athlete's steroid profile. GC/C/IRMS analyses are generally employed to confirm the exogenous origin of the urinary marker having exceeded the population reference range. Nonetheless, those methods are not foolproof and the utilisation of testosterone may well remain undetected. A strategy based upon individual athlete's steroid profiling should be adopted in order to pick up variations that would trigger further IRMS analysis and investigations.