Rôle de l'histopathologie dans le diagnostic des syndromes lymphoprolifératifs B chroniques

In chronic lymphoproliferative B-cell disorders, when cytology and phenotype are not typical of B-CLL, a biopsy (lymph node, bone marrow) or a splenectomy is often performed for the precise diagnosis of this small B-cell lymphoma. The authors underline the histopathological and immunohistochemical criteria for the classification of these lymphomas. They also underline the pitfalls according to the tissue analysed for the diagnosis. They insist on the importance of a good pre-analytical conditioning of the samples depending on the clinician, surgeon, pathologist, technician and of a multidisciplinary approach for the optimal diagnosis.