Exploration biologique du foie en pédiatrie

Jaundice, hepatomegaly, oedema are manifestations usually 0689 1474V 2 observed in pediatric liver disease. Standard hepatic profile must be completed by appropriate investigation to evaluate gravity and to precise etiology. In unconjugated hyperbilirubinemia, the blood bilirubin concentration and time-course, in association with risk factors are important elements for the strict follow-up of the child. Etiological diagnosis (hemolysis, glucuronidation deficiency, hypothyroidy…) must be rapidly performed, for immediate specific treatment is needed in some cases. Jaundice with conjugated hyperbilirubinemia strongly suggests cholestasis. Etiological diagnosis needs appropriate investigation, according to the clinical, radiological and histological status. Intrahepatic cholestasis are frequent during neonatal period with various mechanisms. Other liver modification as hepatomegaly should be also rapidly investigated to identify the cause.