Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7672650 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | 2014 | 6 Pages |
Abstract
The DNA binding potency of the synthesized guanidines (1-6) were determined by UV-Vis spectrophotometer and cyclic voltammeter by keeping the concentration of the compounds constant (A) while varying the amount of DNA (B-H). All the compounds showed electrostatic mode of interaction with DNA having impressively high binding constants values (9.9Â ÃÂ 104-1.3Â ÃÂ 105 (Mâ1)). The compounds also showed good antioxidant activities. These two parameters are helpful to design new anticancer drugs.
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Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Rukhsana Gul, Amin Badshah, Azim Khan, Asif Junaid, Muhammad Khawar Rauf,