Synchronous detection of ebolavirus conserved RNA sequences and ebolavirus-encoded miRNA-like fragment based on a zwitterionic copper (II) metal-organic framework

A 3D MOF of {[Cu(Cmdcp)(phen)(H2O)]2·9H2O}n (1) loaded with two fluorophore-labeled nucleic acids was used as a specific and efficient sensing platform for the simultaneous detection of ebolavirus conserved RNA sequences and ebolavirus-encoded microRNA-like fragment through synchronous fluorescence analysis.300