Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7681603 | Talanta | 2013 | 10 Pages |
Abstract
The method was applied to several binary mixtures of cisplatin and [Cu(1,10-orthophenanthroline)2(H2O)](ClO4)2, Cu(1,10-orthophenanthroline)(H2O)2(ClO4)2 or [Cu(1,10-orthophenanthroline)2(imidazolidine-2-thione)](ClO4)2. The cytotoxicity of the two drugs, alone and in combination, was determined against human acute T-lymphoblastic leukemia cells (CCRF-CEM). For all systems, a synergistic effect was found for selected combinations.
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Authors
Tiziana Pivetta, Francesco Isaia, Federica Trudu, Alessandra Pani, Matteo Manca, Daniela Perra, Filippo Amato, Josef Havel,