Article ID Journal Published Year Pages File Type
7683450 Talanta 2013 7 Pages PDF
Abstract
► Voltammetric experiments allowed selective examination and determination of binding constant of Tl(I) with guanine N-7 in DNA. ► The presence of Tl(I) depresses the activity of doxorubicine vs. DNA. ► Tl(I) itself does not damage DNA nor changes its conformation. ► ROS drastically increase the damaging activity of Tl(I).
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Preview
Voltammetric and electrochemical gravimetric selective detection of interactions between Tl(I) and guanine and the influence on activity of DNA drug-intercalators
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