Development and validation of a sensitive enantiomeric separation method for new single enantiomer drug levornidazole by CD-capillary electrophoresis

Article ID	Journal	Published Year	Pages	File Type
7683710	Talanta	2013	6 Pages	PDF

Abstract

âº An enantioseparation CE method was developed for the analysis of levornidazole. âº The method is rapid and total analysis time is 7Â min, which is much faster than the LC method (65Â min). âº The method is quite sensitive and determines chiral impurity at a 0.05% level. âº A short end injection was applied to decrease the analysis time.

Keywords

hydroxypropyl-β-CD S-β-CD CM-β-CD CSPs Chiral capillary electrophoresis HP-β-CD BGE API background electrolyte Migration time cyclodextrins coefficient of determination Chiral stationary phases levornidazole Active Pharmaceutical Ingredient Resolution CdS quality control