Article ID Journal Published Year Pages File Type
7686389 Talanta 2012 12 Pages PDF
Abstract
► FTIR microscopy distinguished the anticancer mode of action of the test compounds against U937 cells, with the most effective being melphalan, followed by Pinus kesiya and Cratoxylum formosum extracts. ► All compounds raised the intensity of the β-pleated sheet higher than that of the control with the shift of α-helix band and alteration of the secondary structure of the protein band. ► The difference in IR intensity associated with lipids, proteins and nucleic acids were responsible for discrimination of the anticancer mode of action of each compound.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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