| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7686505 | Talanta | 2012 | 11 Pages |
Abstract
⺠Methadone (MET) and Flunitrazepam (FNZ) are frequently co-abused drugs. ⺠Rapid and sensitive UPLC-MS/MS assay for simultaneous quantification of FNZ, MET and metabolites. ⺠The assay could be used for pharmacokinetic and forensic applications. ⺠Full validation was performed over a wide linearity range (LOQ=0.5 ng/mL, ULOQ=2000 ng/mL). ⺠The method was applied on real human samples and in a pharmacokinetic interaction study in animals.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Béla Kiss, Catalina Bogdan, Anca Pop, Felicia Loghin,