Article ID Journal Published Year Pages File Type
7686505 Talanta 2012 11 Pages PDF
Abstract
► Methadone (MET) and Flunitrazepam (FNZ) are frequently co-abused drugs. ► Rapid and sensitive UPLC-MS/MS assay for simultaneous quantification of FNZ, MET and metabolites. ► The assay could be used for pharmacokinetic and forensic applications. ► Full validation was performed over a wide linearity range (LOQ=0.5 ng/mL, ULOQ=2000 ng/mL). ► The method was applied on real human samples and in a pharmacokinetic interaction study in animals.
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
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