| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7686913 | Talanta | 2011 | 17 Pages |
Abstract
Lipophilicity properties have long been considered a vital component of drug discovery and development, providing insight into the role of molecular properties in the biological activity of known and new compounds. An extensive survey of the literature published in analytical and pharmaceutical chemistry journals has been conducted. Separation, optical, electrochemical and calculation methods which were developed and used for determination of lipophilicity non-steroidal anti-inflammatory agents and cephalosporin antibiotics in drugs and biological materials, have been reviewed. This review covers over 100 miscellaneous methods. Presented review highlighted some recent developments and new techniques that have been used in the lipophilicity detection of two different kinds of drugs.
Keywords
dimyristoylphosphatidylcholineCHIHSAADMEBMCLSERTLCRP-HPLCpKaILCRBCsLSSdMPCMOPSRP-LCQSRRQSTRRP-TLCo-Nitrophenyl octyl etherPharmaceutical profilingQRARo-NPOEmigration indexoctanol–waterNSAIDSCOXDCEPSARed blood cells1H NMR1,2-dichloroethane1,2-propanediolAUCBSADMSOO/WVIshuman serum albuminbovine serum albuminProstate specific antigencyclooxygenaseUltravioletHomoTemhighest occupied molecular orbitalQSPRlarge unilamellar vesicleQSARDissociation constantNon-steroidal anti-inflammatory drugsDimethyl sulfoxideQuantitative structure retention relationshipQuantitative Structure Activity Relationshipcarbon nuclear magnetic resonance13C NMRBlood–brain barrierBBBCephalosporinsChromatographic hydrophobicity indexEnhancement factoroctanol–water partition coefficientDistribution coefficientCorrelation coefficientMass spectroscopyImmobilized artificial membraneVisibleLUMOLUVLipophilicitySUVCSFCerebrospinal fluidMeSIAMmorpholinepropanesulfonic acidTransmission electron microscopyMicroemulsionsMolecular weightPappproton nuclear magnetic resonancethin layer chromatographyImmobilized liposome chromatographyReversed phase high performance liquid chromatographyhigh performance liquid chromatographyReversed phase liquid chromatographyHPLCBiopartitioning micellar chromatographyunbound fractionLowest Unoccupied Molecular OrbitalAIDSmall unilamellar vesicle
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Monika DÄ
browska, MaÅgorzata Starek, Jerzy SkuciÅski,