Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7687153 | Talanta | 2012 | 8 Pages |
Abstract
⺠The development of a UPLC-MS/MS method for in vitro CYP activity determination. ⺠A generic, fast gradient for detection of all metabolites. ⺠The method was fully validated for precision, accuracy and selectivity. ⺠Despite absolute matrix effects, no relative matrix effects were observed. ⺠Low activities in diseased liver samples were successfully detected.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Lies De Bock, Koen Boussery, Pieter Colin, Julie De Smet, Huybrecht T'Jollyn, Jan Van Bocxlaer,