Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7687690 | TrAC Trends in Analytical Chemistry | 2018 | 25 Pages |
Abstract
The development of more potent metal-based drugs relies heavily on the understanding of their behavior in biological environments. Although the specific physicochemical properties of metal ions and their coordination compounds allow the application of element-specific techniques to track their fate after administration to a living organism, the ease of ligand exchanges makes speciation and target identification a challenge. In this review, we discuss selected examples of novel analytical metallomics methods utilizing mass spectrometric detectors often hyphenated with separation systems, and their application to anticancer metallodrug research. An emphasis is put on how these techniques help research to advance in this important scientific area with the ultimate ambition of introducing new anticancer agents into clinical development and use.
Keywords
MudPITESICZETFCMetallodrugsMetallomicsSECTransferrinNanoSIMSICPHSAPCAhuman serum albuminCapillary zone electrophoresismatrix-assisted laser desorption/ionizationMode of actionLOD یا Limit of detectionSIMSIMSsecondary ion mass spectrometryMass spectrometryXRFMALDIlimit of detectionX-ray fluorescence microscopyStructured illumination microscopyinductively coupled plasmaSize exclusion chromatographyTurbulent flow chromatographyhigh performance liquid chromatographyHPLCIon chromatographyelectrospray ionization
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Hannah U. Holtkamp, Christian G. Hartinger,